ProVision® is a further innovative formulation by Dr. Pierpaoli, a useful dietary supplement to prevent eye disease, one of the unpleasant effects of ageing.
The ProVision® formulation has been developed on the basis of a clinical trial.
Ingredients :
LUTEIN, DRIED BLUEBERRY EXTRACT, ZEAXANTHIN, ASTAXANTHIN, MELATONIN, VITAMIN A, VITAMIN E, SELENIUM, ZINC , MAQUI .
• Effectiveness proved in a clinical trial (90% of the patients in 6 months) –
• Optimal tolerance and absence of side effects
• Oral application
• Good price (approximately 180 Euros per year)
Further beneficial effects of ProVision® are:
• It controls eye pigmentation regulating the light reaching the photoreceptors
• It scavenges hydroxyradicals
• It protects the retinal epithelium (RPE) from oxidative damage
• It reestablishes circadian rhythms and improves repair processes
• It helps to rebalance the endocrine system
ProVision Pierpaoli
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ProVision® is a further innovative formulation by Dr. Pierpaoli, a useful dietary supplement to prevent eye disease, one of the unpleasant effects of ageing. The ProVision® formulation has been developed on the basis of a clinical trial.
spaziatore
The advantages of the therapy with ProVision®
• Effectiveness proved in a clinical trial (90% of the patients in 6 months) –
• Optimal tolerance and absence of side effects
• Oral application
• Good price (approximately 180 Euros per year)
Further beneficial effects of ProVision® are:
• It controls eye pigmentation regulating the light reaching the photoreceptors
• It scavenges hydroxyradicals
• It protects the retinal epithelium (RPE) from oxidative damage
• It reestablishes circadian rhythms and improves repair processes
• It helps to rebalance the endocrine system
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The extensive use of computers, television, videogames and permanent artificial lights for hours every day, along with low humidity at home and in office, greatly stress and strain our eyes. In particular they “wear out” and “use up” the visual cells of the retina, which are “thirsty” for oxygen and minerals. Additionally, when they are stressed by an intense and variable light of changing wavelength (for example in discotheques), they tend to degenerate.
Our eyes have not been created to be exploited all the time! With an advancing age, one of the major risks is the so-called “macular degeneration,” a progressive chronic disease of the central focal vision of the retina, namely the macular. This essential section of the retina slowly degenerates until its function is totally lost (blindness). The degeneration of the macular in the retina represents the main cause of blindness among the over-50s in the industrialized countries. For example in Italy, according to recent estimates, just under one million people showed the first symptoms of macular degeneration.
According to the World Health Organization, 41% of blindness, (including partial), observed in countries enjoying a high standard of life, are due to macular degeneration.
Recent data shows, nine out of ten people use their computer daily at work, or to study or to play games. Their destiny will inevitably be to develop one of the many visual problems. In recent years, the number of those who spend too many hours in front of a computer monitor has dramatically increased and now appears to involve about 88% of the computer-dependent population.
On the basis of recent polls carried out in numerous European countries and in the United States, the majority of people are either not aware of, or underestimate the risks of being exposed every day (and in some cases even at night!) to the computer monitor. This danger is undervalued, and prevention is often totally neglected.
Rules and guidelines exist to control those using a computer in the work place, but unfortunately these recommendations are far to often neglected.
Even the places and rooms where we live or go out can be noxious for our sight. In discotheques, for example, the “assault” of a huge variety of wavelengths at high frequency cannot be “digested” by our eyes, which have for millennia been used to oil lamps and candles. Excessive heating of rooms produces a permanent dryness and dehydration of the eyes, irritating the conjunctiva and causing damage to the vitreous body.
Driving the car, night and day, requires a relentless effort for attention and adaptation to lights and distances. In addition, night vision requires an adaptation performed by retinal cells (rods and cones), whose pigments are necessary to see in twilight.
Secretion of tears is physiologically reduced during aging, in particular in menopausal women. This fact is dependent on an obvious modification of the hormonal balance. However, dry eyes are commonly produced in ambient environmental conditions (heated rooms with no humidification) and by air pollution. Also people sitting for hours every day (and/or night) in front of a computer can develop dry eyes.
It is therefore of paramount importance to protect our sight and vision by protecting the retina!
Fortunately, a solution to help maintain the integrity of your eyes now exists with ProVision® Dr. Pierpaoli®
Dr. Walter Pierpaoli has been spent almost 50 years studying all pathologies linked to the retina, to ageing of the eyes in general and to the damage produced to the respiratory enzymes of the retina by excessive and direct light. He published his first relevant results originally in 1961!
The formulation ProVision® Dr. Pierpaoli® has been elaborated with the aim to provide the full metabolic and oxidative needs of the eyes and in particular of the retina.
One daily tablet of ProVision® at bedtime is a valid support for the nutritional maintenance of your sight!
Since it is difficult to correct all our habits and working needs, we must help our eyes with a proper support of mineral salts and also of valid active biological substances.
ProVision® contains all the necessary elements for the health of our eyes. It is a formulation consisting of:
LUTEIN, DRIED BLUEBERRY EXTRACT, ZEAXANTHIN, ASTAXANTHIN, MELATONIN, VITAMIN A, VITAMIN E, SELENIUM, ZINC
The ProVision® Formula of Dr. Pierpaoli® has been created by selecting the best ingredients in a highly purified form.
ProVision® averts the onset of all problems affecting your eyes and visual acuity
ProVision® literally feeds your eyes, retina, macula and also your lenses.
ProVision® maintains your eyes in good health, night and day
ProVision® improves problems linked to visual fatigue
Moreover, ProVision® represents a necessary remedy for all those persons who will encounter a macular degeneration at some point due to their own “physiological ageing”. It is expected to affect many young people due to their lifestyle and bad nutrition habits.
One tablet of ProVision® every day half an hour before bedtime or at bedtime is a very valid remedy for the nutritional support of our eyes.
Age-related macular degeneration (ARMD) is the leading cause of severe visual loss in older people, in fact it is the main cause of central vision loss (blindness) in the USA today for those over the age of fifty; (Source: American Academy of Ophthalmology).
ARMD: A growing problem ARMD is the most common form of all eye disorders
(Source: A. Chopard et al. Age related macular degeneration. BMJ 2003, 326: 485-488)
1 in 50 persons over the age 50 and 1 in 5 persons over age 85 have ARMD (Source: Royal National Institute for the Blind, UK)
Over 2 million Americans have serious eye sight symptoms associated with ARMD (Source: Archives of Ophthalmogy, 2004)
If left unchecked ARMD is estimated to effect 1 in 3 of the population by 2070 (Source: BBC website)
Percent of 976 persons 75 or over
Macular degeneration is a condition where the light sensing cells in the eye’s macula malfunction and eventually cease to work. Often individuals with macular degeneration will notice that straight lines, such as poles, walls or wires appear to be wavy; other symptoms can include blurred text, often with dark or even empty spaces that may block the centre of the field of vision.
Fortunately, macular degeneration rarely results in complete blindness since side vision is usually unaffected, but even so because of its propensity, it has been estimated that more than a million people worldwide are completely blind because of advanced ARMD!
ARMD makes activities that require sharp vision, such as reading or driving, very difficult. A test to determine the presence of ARMD uses a so-called Asmler grid. This involves starring at a central dot to see if the lines around it are affected by blurriness, waviness or even are out of vision altogether.
ARMD background
It is not yet clear how or why ARMD is triggered, although the main cause seems to be the hardening of arteries that supply the retina at the back of the eye. Over time, this deprives the tissues of oxygen and other nutrients that help to protect the retina, the consequence being a gradual deterioration of the vision.
The central part of the retina contains a yellow pigment called macular pigment, which helps to protect the retinal receptors from sunlight, especially from the harmful effects of blue light. The decrease in density of this protective pigment can be linked to poor diet and in people who smoke, the protection from free radical damage is also seen as a key in the prevention of ARMD.
Physicians classify ARMD into two parts, namely in wet and in dry form.
The wet form affects about 15% of patients with ARMD. This form differs from the dry type in that there is a growth of abnormal blood vessels under the retina. This can lead to bleeding and scarring and results in a more rapid and severe progression of the disease (when compared to the dry form). Luckily for about 70% of patients with the wet form of ARMD they can be treated with laser photocoagulation to help stabilize the vision, or to limit the growth of further abnormal blood vessels.
The dry form affects 85% of patients with ARMD and thankfully is less progressive and not as severe as the wet form, however, up until now there have not been any successfully reported treatments in regard to the reversal of this condition.
At present, most treatments for all ARMD’s have relied heavily upon supplementing the patients with nutritional elements, particularly lutein and zeaxanthin to alleviate, slow down and sometimes halt its progression.
A recent and new study carried out by Prof. Walter Pierpaoli and by Prof. Changxian Yi from the Ophthalmology Center of Zhongshan University, Gouangzhou, P.R. China, brings now new hope to the millions affected by the degenerative retina disease ARMD (aging-related macula degeneration).
Dr. Pierpaoli and Dr. Changxian Yi studied 100 patients over a period of 2-years in order to evaluate if the daily, evening treatment with the original formula of ProVision® is able to produce any change and improvement in the development and progression of AMD.
Several studies have already shown that lutein, astaxantin and zeaxantin, all of them present in the ProVision® formula, could alleviate, delay and also rarely arrest the progression of the disease. It has already been shown in several animal studies that melatonin, which is also produced by the retina, is able to control eye pigmentation, thus regulating the amount of light reaching the photoreceptors (Pang, S.F. & D.T. Yew. 1979. Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea pigs Cavia porcellus. Experimentia 35: 213-233) and also that melatonin has the capacity to scavenge the toxic hydroxyl radicals from the retina (Tan, D.X., Manchester, L.C., Reiter R.J. et al., 2000. Significance of melatonin in antioxidative defense system: reactions and products. Biol. Sign. Recept. 9: 137-159).
Accordingly, it was reasonable to think that the physiological decrease of melatonin during ageing may be an important factor in the dysfunction of retinal epithelial cells, a well known reason for the onset of AMD, and therefore to study whether melatonin could have an effect on the progress of AMD.
The idea of Dr. Pierpaoli and Dr. Yi was to study and possibly show that the properly studied composition of melatonin, zinc and selenium contained in the original formula of ProVision®, could have the capacity to scavenge and to eliminate the toxic hydroxyl radicals and consequently help to protect the retinal epithelium containing pigments from the oxidative damage of free radicals, also taking into account the extreme avidity of retinal cells for oxygen-dependent phosphorylation for their survival. In fact this damage is considered to be the main cause of AMD. As stated by Dr. Yi, “Our aim was to explore a new approach to the prevention and cure of all kinds of AMDs”.
The approach was straight-forward: first of all, patients with both types of dry and wet AMD were recruited. Then, tablets containing a combination of melatonin, zinc and selenium (3 mg melatonin-Zn-Se, original formula of ProVision® ) were given each night at bedtime (10-12 PM) for a minimum period of 3 months. 55 patients continued the treatment for further 6 months and some of them for 12 and 24 months. All patients were then checked at regular periods in order to measure the extension and the stage of progression of their AMD.
Clinical trial
- 100 patients with both wet and dry ARMD were monitored for 6 months - Subjects took 1 tablet of original formula of ProVision®nightly - The age of patients were 55 to 82, the average age being 71 - Approximately two thirds were men
- Patients were evaluated, including Fundus pictures at the beginning and at every 2-months thereafter
The study reported that at 2-3 months of treatment the visual acuity had been kept stable, (in other words there appeared to be a halting of the progression of ARMD in general). It is worth noting that although this follow-up time is not long, this result is already better than the otherwise normal course that could be expected.
The study reported that at 2-3 months of treatment the visual acuity had been kept stable, (in other words there appeared to be a halting of the progression of ARMD in general). It is worth noting that although this follow-up time is not long, this result is already better than the otherwise normal course that could be expected.
For the patients who continued past 6 months and onto 12 months of nightly use of 1 tablet of the original formula of ProVision® the change in their fundus pictures were remarkable, (please note the “before” and “after” eye fundus pictures presented in figures 1-3).
Figure 1 (above): The left slide shows the eye of a 67 year old male before treatment, his vision had been deteriorating for 2 years. The right picture shows the same eye 2 months later after daily ingestion of 1 tablet of original formula of ProVision® tablets. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage.
Figure 2 (above): The left slide shows the eye of a 71 year old female with ARMD who after 6 months of 1 tablet of original formula of ProVision® daily had her vision improved from 0.2 to 0.4 (as indicated in the right slide).
Figure 3 (above): A 58 year old male whose visual acuity at the start (left slide) was 0.2 improved to 0.4 after 6 months of regular use of 1 tablet of the original formula of ProVision® . The sub-retinal hemorrhage and exudate was remarkably absorbed.
At the end of the study, of the original 110 eyes tested only 8 eyes showed more retinal bleeding and 6 eyes more retinal exudates. In the vast majority there had been dramatically reduced pathologic macular changes. This was confirmed by the patients reporting better vision and general ocular experience with improvements to flare, dryness, clarity and comfort.
Whilst the authors called for larger studies to confirm their findings, they concluded that; “ProVision® Formula supplementation among the aged population may be beneficial in preventing, relieving or reducing the severity of ARMD, which is one of the leading causes of blindness in the elderly.” What is also very important, during the entire period no side effects were observed.